@article {Nikouei:2013:1567-2018:279,title = "Preparation of a Molecularly Imprinted Soft Contact Lens as a New Ocular Drug Delivery System for Dorzolamide",
journal = "Current Drug Delivery",
parent_itemid = "infobike://ben/cdd",
publishercode ="ben",
year = "2013",
volume = "10",
number = "3",
publication date ="2013-06-01T00:00:00",
pages = "279-285",
itemtype = "ARTICLE",
issn = "1567-2018",
url = "http://www.ingentaconnect.com/content/ben/cdd/2013/00000010/00000003/art00004",
keyword = "soft contact lenses, dorzolamide, ocular drug delivery systems, Molecular imprinting, controlled release"
abstract = "In the present work a series of imprinted (MIPs) and non-imprinted (NIPs) hydrogels were prepared using 2-hydroxyethyl methacrylate (HEMA) as a backbone monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker monomer, methacrylic acid (MAA) as a functional monomer and dorzolamide
(DZD) as the template molecule. Different concentrations of MAA (0, 100, 200, 400 mM) were used for preparation of NIPs. Two DZD: MAA molar ratios (1:8 and 1:4) and 400 mM MAA were also applied in imprinting process. The hydrogels (0.4 mm thickness) were synthesized by thermal polymerization
at 50\textdegreeC in 24h in a polypropylene mould. Then, the swelling and binding properties of hydrogels were evaluated in water. Their loading and releasing properties were also studied in NaCl 0.9% and artificial lachrymal fluid. The results showed that using MAA as co-monomer and applying
molecular imprinting technique increased loading capacity of hydrogels. The optimized imprinted hydrogel (MIP1:4), prepared with 400 mM MAA and DZD: MAA molar ratio of 1:4, had the highest affinity for DZD and the greatest ability to control the release process in aqueous media. Our data indicated
that the use of suitable co-monomer and applying a molecular imprinting technique had important influence on loading and releasing properties of hydrogels.",
author = "Nikouei, Bizhan Malaekeh- and Vahabzadeh, Seyedeh Atefeh and Mohajeri, Seyed Ahmad",
}