@article {Ibanez:October 2006:0300-7995:1893,
	author = "Ibanez, Y.",
	author = "Rodriguez, J.M.",
	author = "Lujan, M.",
	author = "Grattan, T.J.",
	author = "Martin, A.J.",
	author = "Burnett, I.",
	title = "A pharmacokinetic study investigating the rate of absorption of a 500 mg dose of a rapidly absorbed paracetamol tablet and a standard paracetamol tablet",
	journal = "Current Medical Research and Opinion",
	volume = "22",
	year = "October 2006",
	abstract = "<I>Objective:</I> A rapidly absorbed tablet formulation of paracetamol containing sodium bicarbonate (PS) has been previously shown to be absorbed at least twice as fast as a standard paracetamol tablet (P) at a 1 g dose. In South America and Asia it is customary for patients to take a 500 mg dose of analgesic. The objective of this pharmacokinetic study was to compare the rate of absorption of PS versus P at a 500 mg dose.<P></P><I>Research design and methods:</I> An open, randomized, single dose, cross-over study. Thirty Hispanic healthy volunteers randomly received a 500 mg dose taken orally with 50 mL of water 2 h after a standard breakfast. Blood samples were taken up to 10 h post-dose. Plasma concentrations of paracetamol were determined by HPLC with UV detection.<P></P><I>Main outcome measures:</I> AUC<SUB>0-30 min</SUB>, <I>C</I><SUB>plasma 30 min</SUB> and <I>T</I><SUB>max</SUB> were analyzed non-parametrically by the Wilcoxon's rank sum test. A linear mixed effects model was used to analyze the logarithmically transformed AUC<SUB>0-&#8733;</SUB> and <I>C</I><SUB>max</SUB>. Bioequivalence was accepted if the 90% confidence intervals (CI) for the ratio of the means of the primary pharmacokinetic variable AUC<SUB>0-&#8733;</SUB> lay completely within the range 0.80-1.25.<P></P><I>Results:</I> AUC<SUB>0-30 min</SUB> and <I>C</I><SUB>plasma 30 min</SUB> were significantly greater and <I>T</I><SUB>max</SUB> was significantly shorter (all <I>p</I> &#60; 0.0001) for PS versus P. The formulations were bioequivalent for AUC<SUB>0-&#8733;</SUB> (90% CI 0.99:1.05) and no statistical difference was seen for <I>C</I><SUB>max</SUB> (95% CI 0.91:1.14).<P></P><I>Conclusions:</I> Paracetamol was absorbed at least twice as fast from PS compared to P at a 500 mg dose. The extent of absorption was equivalent for both formulations.",
	pages = "1893-1897(5)",
	url = "http://www.ingentaconnect.com/content/apl/cmro/2006/00000022/00000010/art00003"
	doi = "doi:10.1185/030079906X132596"
}