@article {Nagaev:July 2001:0006-291X:561,
	author = "Nagaev I.",
	author = "Smith U.",
	title = "Insulin Resistance and Type 2 Diabetes Are Not Related to Resistin Expression in Human Fat Cells or Skeletal Muscle",
	journal = "Biochemical and Biophysical Research Communications",
	volume = "285",
	year = "July 2001",
	abstract = "<P>Resistin is secreted by rodent fat cells and was recently postulated to be an important link between obesity and insulin resistance. We examined Resistin gene expression with real-time RT-PCR in human isolated fat cells, adipose tissue, and muscle from 42 individuals of varying degrees of overweight and who had normal insulin sensitivity or were insulin-resistant or Type 2 diabetic. Resistin was not expressed in human muscle nor was it expressed in most human isolated fat cells or intact biopsies. No difference was found between normal, insulin-resistant, or Type 2 diabetic samples. However, a very low but specific Resistin expression could be demonstrated in isolated fat cells and intact adipose tissue from some individuals (<B>n</B> = 3 and <B>n</B> = 4, respectively). There was no evidence for the expression of splice variants in the human samples. Thus, Resistin does not seem to be an important link to insulin resistance and Type 2 diabetes in human. <B>Copyright 2001 Academic Press.</B></P>",
	pages = "561-564(4)",
	url = "http://www.ingentaconnect.com/content/ap/rc/2001/00000285/00000002/art05173"
}