@article {Yamashita:March 2001:0006-291X:647,
	author = "Yamashita T.",
	author = "Kaneko S.",
	author = "Hashimoto S-i.",
	author = "Sato T.",
	author = "Nagai S.",
	author = "Toyoda N.",
	author = "Suzuki T.",
	author = "Kobayashi K.",
	author = "Matsushima K.",
	title = "Serial Analysis of Gene Expression in Chronic Hepatitis C and Hepatocellular Carcinoma",
	journal = "Biochemical and Biophysical Research Communications",
	volume = "282",
	year = "March 2001",
	abstract = "<P>Hepatitis C virus (HCV) causes chronic hepatitis C (CH-C) and is epidemiologically linked with the occurrence of hepatocellular carcinoma (HCC). To elucidate the comprehensive gene expression profiles of CH-C and HCC, serial analysis of gene expression (SAGE) libraries were made from CH-C and HCC tissues of a patient, and compared with a reported SAGE library of a normal liver (NL). Scatter plots of the distribution of tags from the HCC library exhibited the existence of many differentially expressed genes compared with those from the CH-C and NL libraries. Up-regulation of IFN-gamma inducible genes and oxidative stress-inducible genes were identified in both the CH-C and HCC libraries, and some unpublished new genes were specifically up- or down-regulated in the HCC library. This genome-wide scanning study discloses the molecular portraits of CH-C and HCC, and provides novel candidate genes that should help clarify the mechanism of hepatocarcinogenesis in the chronically HCV-infected liver. <B>Copyright 2001 Academic Press.</B></P>",
	pages = "647-654(8)",
	url = "http://www.ingentaconnect.com/content/ap/rc/2001/00000282/00000002/art04610"
}