@article {Laczay:31 January 2001:0236-6290:31,
	author = "Laczay, P.",
	author = "Semjen, G.",
	author = "Lehel, J.",
	author = "et al,",
	title = "Pharmacokinetics and bioavailability of doxycycline in fasted and nonfasted broiler chickens",
	journal = "Acta Veterinaria Hungarica",
	volume = "49",
	year = "31 January 2001",
	abstract = "The pharmacokinetics and the influence of food on the kinetic profile and bioavailability of doxycycline was studied after a single intravenous (i.v.) and oral dose of 10.0 mg/kg body weight in 7-week-old broiler chickens. Following i.v. administration the drug was rapidly distributed in the body with a distribution half-life of 0.21 &#177; 0.01 h. The elimination half-life of 6.78 &#177; 0.06 h was relatively long and resulted from both a low total body clearance of 0.139 &#177; 0.007 L/h&#183;kg and a large volume of distribution of 1.36 &#177; 0.06 L/kg. After oral administration to fasted chickens, the absorption of doxycycline was quite fast and substantial as shown by the absorption half-life of 0.39 &#177; 0.03 h, the maximal plasma concentration of 4.47 &#177; 0.16 &#181;g/mL and the time to reach the C<SUB>max </SUB>of 1.73 &#177; 0.06 h. The distribution and the final elimination of the drug were slower than after i.v. administration. The absolute bioavailability was 73.4 &#177; 2.5&#037;. The presence of food in the intestinal tract reduced and extended the absorption (t<SUB>1/2a</SUB> = 1.23 &#177; 0.21 h; C<SUB>max</SUB> = 3.07 &#177; 0.23 &#181;g/mL; t<SUB>max</SUB> = 3.34 &#177; 0.21 h). The absolute bioavailability was reduced to 61.1&#037; &#177; 4.4&#037;.",
	pages = "31-37(7)",
	url = "http://www.ingentaconnect.com/content/akiado/avh/2001/00000049/00000001/art00005"
}