@article {Shemer:2008:1174-5886:29,
	author = "Shemer, Avner",
	author = "Amichai, Boaz",
	author = "Trau, Henri",
	author = "Nathansohn, Nir",
	author = "Mizrahi, Boaz",
	author = "Domb, Abraham J.",
	title = "Efficacy of a Mucoadhesive Patch Compared with an Oral Solution for Treatment of Aphthous Stomatitis",
	journal = "Drugs in R&D",
	volume = "9",
	year = "2008",
	abstract = "<B>Objective:</B> The purpose of this study was to evaluate the efficacy and tolerability of a mucoadhesive patch compared with a pain-relieving oral solution for the treatment of aphthous stomatitis.<P></P><B>Methods:</B> Patients with active aphthous stomatitis were randomly treated either once a day with a mucoadhesive patch containing citrus oil and magnesium salts (n = 26) or three times a day with an oral solution containing benzocaine and compound benzoin tincture (n = 22). All patients were instructed to apply the medication until pain had resolved, and completed a questionnaire detailing multiple clinical parameters followed by an evaluation of the treatment.<P></P><B>Results:</B> The mucoadhesive patch was found to be more effective than the oral solution in terms of healing time (mean &#177; SD: 36.0 &#177; 22.8 hours vs 134.7 &#177; 57.7, p &#60; 0.001) and pain intensity after 12 and 24 hours (3.7 &#177; 2.8 vs 6.3 &#177; 2.6, p = 0.003, and 2.3 &#177; 2.7 vs 5.7 &#177; 2.5, p &#60; 0.001, respectively). Local adverse effects 1 hour after treatment were significantly (p &#60; 0.01) less frequent among the mucoadhesive patch patients compared with the oral solution patients.<P></P><B>Conclusions:</B> The mucoadhesive patch was found to be significantly more effective and better tolerated than the oral solution in the treatment of aphthous stomatitis.",
	pages = "29-35(7)",
	url = "http://www.ingentaconnect.com/content/adis/rdd/2008/00000009/00000001/art00003"
}