@article {Deeks:2006:0012-6667:1863,
	author = "Deeks, Emma D.",
	author = "Scott, Lesley J.",
	title = "Pioglitazone/Metformin",
	journal = "Drugs",
	volume = "66",
	year = "2006",
	abstract = "&#9652; A fixed-dose pioglitazone/metformin tablet is approved in the US and the EU for the treatment of adult patients with type 2 diabetes mellitus who currently have inadequate glycaemic control with metformin monotherapy. In the US, the combination tablet is also approved for the treatment of adult patients with type 2 diabetes who currently have inadequate glycaemic control with pioglitazone monotherapy and for those already receiving a combination of pioglitazone and metformin.<P></P>&#9652; Bioequivalence, based on absorption and bioavailability parameters, has been established between the fixed-dose tablets and equivalent doses of pioglitazone and metformin coadministered as separate agents.<P></P>&#9652; Combination therapy with pioglitazone plus metformin was significantly more effective at improving both glycaemic and lipid control than metformin plus placebo in patients with type 2 diabetes in a 16-week, well designed trial.<P></P>&#9652; Pioglitazone plus metformin demonstrated similar antihyperglycaemic efficacy to that of rosiglitazone plus metformin in a well designed 12-month trial; however, pioglitazone plus metformin was the superior combination in terms of lipid control.<P></P>&#9652; In several comparative trials of 1-3.5 years&#39; duration, pioglitazone plus metformin was at least as effective as combination therapy with a sulphonylurea plus metformin in terms of antihyperglycaemic efficacy, but provided superior lipidaemic control with regard to levels of triglyceride and high-density lipoprotein-cholesterol.<P></P>&#9652; Pioglitazone plus metformin was generally well tolerated in patients with type 2 diabetes, with adverse events common to metformin monotherapy observed at a similar incidence to that with metformin plus placebo.",
	pages = "1863-1877(15)",
	url = "http://www.ingentaconnect.com/content/adis/dgs/2006/00000066/00000014/art00007"
}