@article {Kalpaklioglu:May 2005:1081-1206:581,
	author = "Kalpaklioglu, Ayse F.",
	author = "Kara, Turkan",
	author = "Kurtipek, Ercan",
	author = "Kocyigit, Pinar",
	author = "Ekici, Aydanur",
	author = "Ekici, Mehmet",
	title = "Evaluation and impact of chronic cough: comparison of specific vs generic quality-of-life questionnaires",
	journal = "Annals of Allergy, Asthma and Immunology",
	volume = "94",
	year = "May 2005",
	abstract = "Background: Chronic cough is a common condition that has a significant impact on health-related quality of life (HRQoL).<P></P> <P></P> Objective: To investigate whether chronic cough is associated with adverse psychological and physical effects on quality of life (QoL) using different HRQoL questionnaires.<P></P> <P></P> Methods: Forty patients were recruited for the study. The diagnostic workup was mainly based on the pathogenic triad in chronic cough: postnasal drip syndrome, asthma, and gastroesophageal reflux disease. The HRQoL was evaluated with the cough-specific quality-of-life questionnaire (CQLQ), Leicester Cough Questionnaire (LCQ), Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), and Hospital Anxiety and Depression Scale.<P></P> <P></P> Results: Symptom scores were significantly correlated with the CQLQ and LCQ (<IMG SRC="/iso-ents/isogrk1/bgr-s.gif" ALT="bgr"> = .415 and <IMG SRC="/iso-ents/isogrk1/bgr-s.gif" ALT="bgr"> = -.272, respectively) but not with the SF-36. A statistically significant difference was found in all questionnaires, except the physical component summary domain of the SF-36, after specific therapy. Correlation between the 2 specific HRQoL questionnaires was moderate to high when pretreatment and posttreatment scores were compared (<I>r</I> = -0.42 and <I>r</I> = -0.60). Concurrent validity of the LCQ was higher than the CQLQ when compared with the SF-36 domains. The effect size of each specific QoL questionnaire was 1 or higher after treatment, whereas it was much less in the SF-36. There was no change in depression with treatment despite anxiety. Posttreatment symptom scores were related with anxiety (<I>r</I> &#062; 0.40)<P></P> <P></P> Conclusions: Because HRQoL is important to patients, a cough-specific HRQoL instrument, either the CQLQ or LCQ, should be routinely used to optimally evaluate the impact of cough on patients and to evaluate the efficacy of cough-modifying agents.",
	pages = "581-585(5)",
	url = "http://www.ingentaconnect.com/content/acaai/aaai/2005/00000094/00000005/art00014"
}